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Charaka Samhita, Chikitsasthana 3.256
Musta... sarva jwara prayojyam -- Musta is applicable to all types of fever. Among the single herbs, Musta is the most broadly useful Jwaraghna (fever-reducing herb), applicable across all Dosha types and combinations.

Classical documentation -- breadth of application

The reason Musta appears in so many disease chapters: its three-way action of Deepana + Pachana + Sheeta Virya addresses the most common pathological combination in classical Ayurveda -- Agni impairment + Ama accumulation + Pitta/heat component. This combination underlies fever, digestive disorders, metabolic conditions (Meda reduction), and skin conditions with internal heat. Charaka Samhita documents Musta in: Jwara (fever), Atisara (diarrhoea), Grahani (malabsorption), Arsha (haemorrhoids), Kustha (skin conditions), Prameha (metabolic conditions -- for its Medohara property), and Stanya (lactation purification -- for its ability to digest Ama in breast milk channels).

Sesquiterpenes and anti-fever research
Cyperus rotundus rhizome contains sesquiterpene compounds including cyperene, alpha-cyperone, and cyperrotundan. Research published in the Journal of Ethnopharmacology documents antipyretic (fever-reducing), anti-inflammatory, and antispasmodic properties consistent with the classical Jwaraghna and Shoolahara documentation.