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Charaka Samhita, Sutrasthana 25.45
Na kinchid aushavam loke yad apathyam matam sadaa / Nahi sarvatra sarvasya sarvada hi pathyam na cha — There is nothing in the world that is always Apathya, nor is anything always Pathya for everyone everywhere at all times. Context — constitution, condition, season, and quantity — determines all.

The classical framework — four determinants

Prakriti (constitution): What is Pathya depends first on Prakriti. Sour, salty, warm foods that are Pathya for Vata constitution are Apathya for Pitta. Heavy, nourishing foods Pathya for Vata and Pitta may be Apathya for Kapha. No food list is valid without the constitutional context.

Vikriti (current condition): A food that is appropriate for the baseline constitution may be Apathya when a specific condition is active. Milk is generally Pathya for Pitta — but is Apathya in active fever (Jwara) and in Kapha respiratory conditions. The Vikriti assessment overrides the baseline Prakriti assessment in acute conditions.

Ritu (season): Pathya and Apathya change with season. Heavy, oily, sweet foods are Pathya in Hemanta (winter — when Agni is strongest) and Apathya in Varsha (monsoon — when Agni is weakest). The Ritucharya framework documents season-specific Pathya and Apathya for each of the six classical seasons.

Matra (quantity): Charaka Samhita's most important Pathya principle: "Even nectar becomes poison in excess; even poison becomes medicine in the right dose." The classical concept of Satmya (habituation) also modifies the assessment — a food that would be Apathya for a naive individual may be Pathya for someone who has been consistently consuming it in moderation over a long period.

Classical universally beneficial foods

Despite the contextual principle, Charaka Samhita documents a small list of foods considered broadly Pathya across most constitutions and conditions: Shali rice (old red or white rice — Oryza sativa) — the most consistently documented Pathya grain across all disease chapters; Yusha (lentil soup, particularly moong dal — Vigna radiata) — easy to digest, tridoshic in prepared form; Rock salt (Saindhava — the most balanced salt); Ghrita (cow's ghee) — documented as tridoshic in moderate use; Warm water — universally Pathya; Amalaki — the Rasayana that is Pathya across all constitutions.

Classical universally problematic foods

Charaka Samhita also documents foods that are broadly Apathya across most contexts: day-old food (Paryushita — fermented beyond the classical preparation); food eaten before the previous meal is digested; food eaten in excessive quantity; Viruddha (incompatible combination) food; food eaten in anger, grief, or distraction; excessively processed food (Krtanna that has lost its natural qualities through excess processing).

The Nitya Sevaniya and Nitya Asevaniya
Charaka Samhita, Sutrasthana 7 documents two lists: Nitya Sevaniya (foods for daily use — Shali rice, moong, rock salt, rainwater, warm water, ghee) and foods to be avoided daily. The Nitya Sevaniya list reflects the classical ideal of a maintenance diet. These are not the only foods — they are the most consistently beneficial foundation foods that can be eaten daily without accumulating imbalance.