Charaka Samhita, Chikitsasthana 15.38
Agnih pachati bhaktam cha — It is Agni that digests food, Agni that produces Varna (complexion), Agni that produces Bala (strength), Agni that produces Ayu (lifespan), Agni that produces Aarogya (health), Agni that produces Ojas. When Agni is extinguished, the person dies.

1. Jatharagni — the primary fire

The one primary digestive fire in the Amashaya (stomach and small intestine). All other Agni in the body depend on the strength of Jatharagni. Charaka Samhita, Chikitsasthana 15 states: 'All other Agni are born from and sustained by Jatharagni. When Jatharagni is healthy, all 12 subsidiary Agni are healthy. When Jatharagni is impaired, all subsidiary Agni are impaired simultaneously.' This is why Agni management always begins with Jatharagni — the root that sustains all other metabolic fires.

2–6. Bhutagni — the five elemental fires

Five fires corresponding to the five Panchamahabhuta: Prithvi Agni (Earth element processing), Jala Agni (Water), Agni Agni (Fire element), Vayu Agni (Air), Akasha Agni (Space). After Jatharagni processes food into Ahara Rasa (food essence), the Bhutagni process the element-specific components of the food. Each Bhutagni processes the elements in food that correspond to its own element — the Prithvi component of food is processed by Prithvi Agni and nourishes the Prithvi component of the body's tissues. This is the mechanism behind the classical principle that 'similar nourishes similar' at the elemental level.

7–13. Dhatvagni — the seven tissue fires

Seven tissue-specific fires, one per Dhatu — Rasa Dhatvagni, Rakta Dhatvagni, Mamsa Dhatvagni, Meda Dhatvagni, Asthi Dhatvagni, Majja Dhatvagni, and Shukra Dhatvagni. After the Bhutagni have processed the food essence, the Dhatvagni sequentially convert it into progressively finer tissues. Rasa Dhatvagni is first — it processes the post-Bhutagni essence into Rasa Dhatu. A portion of Rasa Dhatu then becomes the raw material for Rakta Dhatvagni, and so on through the seven. Full documentation: Dhatu pages.

The chain — why one impairment cascades
If Jatharagni is impaired, all downstream Agni are weakened. If Rasa Dhatvagni is specifically impaired, Rasa quality is poor — which means Rakta Dhatvagni receives poor-quality raw material, producing poor-quality Rakta. The cascade continues through all seven Dhatu. This is why classical treatment always begins with strengthening Jatharagni — restoring the root fire automatically improves all downstream processing. Administering tissue-specific herbs (e.g. iron for anaemia) without first restoring Jatharagni is documented as producing incomplete results.