Charaka Samhita, Chikitsasthana 15.50
Sama vishama Tikshna Manda — Balanced, irregular, sharp, and slow. These four states of Agni produce, respectively: health, Vata diseases, Pitta diseases, and Kapha diseases. The entire disease classification ultimately traces to one of these four Agni states.

Sama Agni — the balanced state

Signs: food digests in the appropriate time (3–5 hours for a normal meal); genuine hunger at meal times but no urgency or distress; stool is well-formed, passed once daily with ease; tongue is clear; mind is clear and energised after eating; no bloating, burning, or heaviness. Charaka Samhita documents Sama Agni as the state in which Ojas is produced from every meal — the body is operating at optimal metabolic efficiency.

Vishama Agni — irregular (Vata imbalance)

Signs: highly variable digestion — strong appetite at some meals, absent at others; bloating and gas after some foods but not others; inconsistent stool (sometimes constipated, sometimes loose); food sometimes digests quickly, other times sits heavily for hours. Associated with Vata aggravation — Vata's inherent variability expressing through the digestive fire. Treatment: Vata-reducing diet and Deepaniya herbs that specifically address Vishama Agni — particularly Shunthi (dry ginger), which is documented as specifically Vishama Agni-balancing.

Tikshna Agni — sharp/intense (Pitta imbalance)

Signs: strong, persistent hunger; food digests very quickly (sometimes within 1–2 hours of eating); burning sensation in stomach and chest (hyperacidity); loose stools; intense desire for food; irritability when meals are delayed; possible hypoglycaemia-type symptoms between meals. Associated with Pitta aggravation. Treatment: Pitta-reducing diet, avoiding Trikatu and other strongly Deepaniya herbs (they will over-kindle an already-sharp fire), using Madhura (sweet) and Sheeta (cooling) preparations like Shatavari Ghrita and Yashtimadhu.

Manda Agni — slow/dull (Kapha imbalance)

Signs: food takes a very long time to digest (6+ hours); loss of appetite; heaviness after eating; lethargy; excess mucus production; weight gain even with moderate food intake; sluggish bowels. Associated with Kapha aggravation. Treatment: the most Deepaniya herbs are appropriate here — Trikatu, Chitraka, Pippali. Fasting and exercise are both specifically indicated for Manda Agni. Snehapana (internal ghee) is contraindicated until Manda Agni is corrected.

Assessment — tongue, stool, and appetite
The three most reliable clinical assessments of Agni state: tongue coating (Sama: clear; Vishama: patchy coating in some areas; Tikshna: red, inflamed edges; Manda: thick white-yellow coating throughout); stool (Sama: well-formed, easy; Vishama: variable; Tikshna: loose, urgency; Manda: heavy, slow, mucus); and appetite pattern (Sama: regular, moderate; Vishama: variable; Tikshna: intense, frequent; Manda: weak or absent).
Why the same herb can help or harm
Trikatu is beneficial for Manda Agni (kindles the slow fire) but harmful for Tikshna Agni (further inflames an already sharp fire). Shatavari Ghrita is beneficial for Tikshna Agni (cools and nourishes) but potentially problematic for Manda Agni (too nourishing for a system that cannot yet process it). This is why Agni assessment always precedes herb prescription in classical Ayurveda — the same symptom (digestive difficulty) can arise from any of the four states, and the treatment for each is different.