Charaka Samhita, Sutrasthana 28 — Dhatu 6
Majja Dhatu: Karma — Sneha (oleation), filling of bones. Seat — Bones. Upadhatu — Skin oiliness. Mala — Tears (Akshi Sneha) and oiliness of skin.

Classical documentation

Majja Dhatu encompasses both bone marrow and the nervous tissue (neural elements in the brain and spinal cord). This dual classification — Majja as both marrow and neural tissue — reflects the classical observation that both share the quality of being enclosed within hard bone (skull and vertebral column), both have the same Snigdha-Guru-Mrudu (unctuous, heavy, soft) qualities, and both degenerate together in conditions of advanced Vata aggravation. Modern neurology confirms that bone marrow and neural tissue share developmental origins (neural crest cells) — a convergence with the classical dual classification that was not known when the classical texts were written.

Elements
Agni + Jala
Primary seat
Bones
Primary karma
Sneha (oleation), filling of bones
Channel
Marrow channels — Majjavaha Srotas
Upadhatu
Skin oiliness
Mala
Tears (Akshi Sneha) and oiliness of skin

Signs of imbalance

Vriddhi (excess): Heavy eyes, large joints filled with excess marrow, heaviness throughout

Kshaya (deficiency): Joint pain (empty-feeling joints), dizziness, fainting, vision impairment, neurological weakness

Dhatvagni — the tissue fire
Majja Dhatvagni — impaired in degenerative neurological conditions. When Dhatvagni is impaired — by Ama, improper diet, or Dosha aggravation — the tissue cannot properly form the next Dhatu in the chain. This is why classical treatment of tissue deficiency begins not with tissue-building herbs but with Deepana (kindling the Dhatvagni) and Pachana (digesting the Ama that impairs it).
Rasayana for this Dhatu
Shatavari, Ashwagandha, Bala, Guduchi — nourishing, heavy, unctuous preparations. The classical Rasayana approach to Majja Dhatu: nourish the Dhatvagni first, then provide the specific Dhatu-building raw material through appropriate Rasayana preparations.
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